Time of flight secondary ion mass spectrometry
Collaborating with the group of Nick Winograd in the Penn State Department of Chemistry, imaging with time-of-flight secondary ion mass spectrometry promises measurements of phospholipids in specific regions of neuronal membranes and peptides in single cross fractured vesicles in cells. Here we are particularly interested in understanding the structure and function of membrane segments of high curvature (e.g., vesicles, fusion pores, etc...).
